| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| EGFR | 巴雷特腺癌,脑胶质瘤,癌症,宫颈鳞状细胞癌,脊索瘤,慢性髓性白血病,结直肠癌,上皮性卵巢癌,食管鳞状细胞癌,胃腺癌,多形胶质母细胞瘤,头颈鳞状细胞癌,血液学癌,肺腺癌,肺细胞癌。癌,非小细胞肺癌,小细胞肺癌,恶性胶质瘤,恶性间皮瘤,胰腺腺癌,腹膜间皮瘤,皮肤鳞状细胞癌,幕上多形胶质母细胞瘤 | AEE788,阿法替尼,贝伐单抗,博舒替尼,布加替尼,帕尼单抗,西妥昔单抗,卡奈替尼,克唑替尼,CRS/IPHC,达可替尼,EGFR Inhibitor,厄洛替尼,吉非替尼,埃克替尼,拉帕替尼,MEDI4736,来那替尼，奈拉替尼,尼妥珠单抗,奥希替尼,PF 00299804,PLATINUM,西罗莫司,Rintega,Rociletinib,星形孢菌素,Sym004,TAK-788, | 氟尿嘧啶,顺铂,多西他赛,培美曲塞, | 145 | 431 |
| ERBB2 | 胆道癌,膀胱癌,乳腺癌,结肠癌,结直肠癌,子宫内膜癌,食管癌,胃腺癌,胃食管交界处腺癌,头颈部鳞状细胞癌,肝细胞癌,HER2受体阴性乳腺癌,HER2受体接受治疗或阳性乳腺癌,肺癌,非小细胞肺癌,小细胞癌,卵巢癌,胰腺癌,唾液腺癌,阴囊佩吉特氏病,胃癌,子宫癌,子宫体子宫内膜癌癌,子宫体浆膜腺癌 | A66,Ado-trastuzumab,阿法替尼,AKTi-1/2,博舒替尼,Capecitabin,卡培他滨,Capecitibine,西妥昔单抗,达可替尼,厄洛替尼,吉非替尼,伊布替尼,拉帕替尼,Leucovorin,来那替尼，奈拉替尼,哌柏西利,帕博西尼,帕博西林,帕尼单抗,帕妥珠单抗,Pictilisib,PLATINUM,Torkinib,雷莫芦单抗,西罗莫司,Tgx-221,曲妥珠单抗,XL147 (Pilaralisib), | 氟尿嘧啶,多西他赛,吉西他滨,伊立替康,奥沙利铂,紫杉醇,唑来膦酸, | 42 | 139 |
| ESR1 | 乳腺癌,雌激素受体阳性乳腺癌 | Aromatase Inhibitor,氟维司群,Hormone Therapy,来曲唑片,哌柏西利,帕博西尼,帕博西林, | 他莫昔芬, | 9 | 22 |
| ERBB3 | 乳腺癌,癌症,结直肠癌,非小细胞肺癌,黑色素瘤,胰管腺癌,尿路上皮癌,葡萄膜黑色素瘤 | 9F7-F11,阿法替尼,AV-203,西妥昔单抗,CP-724714,吉非替尼,拉帕替尼,帕妥珠单抗,司美替尼,曲美替尼,曲妥珠单抗, | 6 | 13 | |
| EZH2 | 癌症,结直肠癌,弥漫性大B细胞淋巴瘤,滤泡性淋巴瘤,淋巴瘤,黑色素瘤,骨髓增生异常综合征,皮肤黑色素瘤 | 达拉非尼,EZH2 Inhibitor JQEZ5,GSK126,JQEZ5,UNC1999, | 7 | 11 | |
| ERCC1 | 膀胱癌,非小细胞肺癌 | Cisplatin Concomitant With Gemcitabine,Cisplatine,Gemcitabine Concomitant With Nedaplatin, | 顺铂, | 3 | 7 |
| ERBB4 | 乳腺癌,头颈部鳞状细胞癌,Her2受体阳性乳腺癌,黑色素瘤 | 厄洛替尼,拉帕替尼,曲妥珠单抗, | 4 | 6 | |
| ETV6 | 急性淋巴细胞白血病,血液肿瘤,骨髓增生异常综合征 | 4 | 5 | ||
| EWSR1 | 骨尤因肉瘤,骨外黏液样软骨肉瘤 | 舒尼替尼, | 2 | 4 | |
| EPOR | 小儿B细胞淋巴母细胞白血病,小儿B淋巴细胞白血病 | JAK-STAT Inhibitors, | 1 | 3 | |
| EREG | 结直肠癌,肺腺癌 | 西妥昔单抗,帕尼单抗, | 1 | 3 | |
| ETV4 | 肺癌,胰腺癌,前列腺癌 | 曲美替尼, | 1 | 3 | |
| ERG | 尤因肉瘤,前列腺癌 | 2 | 2 | ||
| EIF4EBP1 | 结直肠癌,胃腺癌 | Dactolisib,依维莫司,Torkinib,WYE354, | 1 | 2 | |
| EPHB2 | 前列腺癌 | 2 | 2 | ||
| EPAS1 | 结直肠癌,肾细胞癌 | 帕唑帕尼,培唑帕尼, | 1 | 2 | |
| ERCC2 | 非小细胞肺癌,骨肉瘤 | 卡铂,顺铂,紫杉醇, | 1 | 2 | |
| ETV1 | 肺癌,胰腺癌 | 曲美替尼, | 1 | 2 | |
| ETV5 | 肺癌,胰腺癌 | 曲美替尼, | 1 | 2 | |
| ERRFI1 | 胆管癌,非小细胞肺癌 | EGFR Inhibitor,厄洛替尼, | 2 | 2 | |
| EGF | 头颈部鳞状细胞癌 | 西妥昔单抗, | 1 | 1 | |
| EIF1AX | 葡萄膜黑色素瘤 | 1 | 1 | ||
| EP300 | 霍奇金淋巴瘤 | 1 | 1 | ||
| EPHB4 | 结直肠癌 | 贝伐单抗, | 1 | 1 | |
| ERCC5 | 顶叶室管膜瘤 | 1 | 1 | ||
| ETS2 | 非小细胞肺癌 | 顺铂,紫杉醇, | 1 | 1 | |
| EPCAM | 林奇综合征 | 1 | 1 | ||
| ECSCR | 癌症 | Antiangiogenic Therapy, | 1 | 1 | |
| EPHA7 | 0 | 0 | |||
| EPHA3 | 0 | 0 | |||
| EPHA5 | 0 | 0 | |||
| EPHB1 | 0 | 0 | |||
| ERCC4 | 0 | 0 | |||
| ERCC3 | 0 | 0 | |||
| E2F3 | 0 | 0 | |||
| EED | 0 | 0 | |||
| EGFL7 | 0 | 0 | |||
| EIF4A2 | 0 | 0 | |||
| EIF4E | 0 | 0 | |||
| ELAC2 | 0 | 0 | |||
| ELANE | 0 | 0 | |||
| ELF3 | 0 | 0 | |||
| EML4 | 0 | 0 | |||
| EPHA2 | 0 | 0 | |||
| EPHA4 | 0 | 0 | |||
| EPHA6 | 0 | 0 | |||
| EPHB6 | 0 | 0 | |||
| ERF | 0 | 0 | |||
| ERICH3 | 0 | 0 | |||
| ERMP1 | 0 | 0 | |||
| ESR2 | 0 | 0 | |||
| EXT1 | 0 | 0 | |||
| EXT2 | 0 | 0 | |||
| EZR | 0 | 0 | |||
| EMSY | 0 | 0 | |||
| EEF1A1 | 0 | 0 | |||
| EGR3 | 0 | 0 | |||
| EIF2AK3 | 0 | 0 | |||
| EIF3A | 0 | 0 | |||
| EIF4G3 | 0 | 0 | |||
| EIF5A | 0 | 0 | |||
| ELF1 | 0 | 0 | |||
| ELF4 | 0 | 0 | |||
| ELL | 0 | 0 | |||
| ELMO1 | 0 | 0 | |||
| ELN | 0 | 0 | |||
| ELOC | 0 | 0 | |||
| EME1 | 0 | 0 | |||
| EME2 | 0 | 0 | |||
| ENG | 0 | 0 | |||
| ENOSF1 | 0 | 0 | |||
| EPC1 | 0 | 0 | |||
| EPHA1 | 0 | 0 | |||
| EPHX1 | 0 | 0 | |||
| EPPK1 | 0 | 0 | |||
| EPS15 | 0 | 0 | |||
| ERCC6 | 0 | 0 | |||
| ERI1 | 0 | 0 | |||
| ETS1 | 0 | 0 | |||
| EXO1 | 0 | 0 | |||
| EXOC2 | 0 | 0 | |||
| EXOSC8 | 0 | 0 | |||
| EYA2 | 0 | 0 | |||
| EZH1 | 0 | 0 | |||
| E2F1 | 0 | 0 | |||
| EBF1 | 0 | 0 | |||
| ECT2L | 0 | 0 | |||
| EDC4 | 0 | 0 | |||
| EDNRA | 0 | 0 |
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